F Frost Lab

Publications

33 papers since 2007

Peer-reviewed work from the Frost Lab and collaborators on placental imprinting, transposable elements, DNA methylation and reproductive epigenetics.

33 results

2025

1 paper

  1. Divergent roles of DNA methylation, TRIM28, and p53 surveillance in human embryonic and trophoblast stem cells

    Saini D, Katz MS, Beck SGA, Ireland TE, Ray S, Niloy AJ, Mazloomnejad R, Fleming A, Vetrici SC, Cinkornpumin JK, Sack T, Duhamel S, Slim R, Park M, Frost JM, Paul S, Martin RC, Pastor WA

    bioRxiv (preprint) DOI ↗

2024

3 papers

  1. Dynamics of DNA methylation and its impact on plant embryogenesis

    Frost JM, Rhee JH, Choi Y

    Current Opinion in Plant Biology DOI ↗

  2. The evolving genetic landscape of telomere biology disorder dyskeratosis congenita

    Tummala H, Walne AJ, Badat M, Patel M, Walne AM, Alnajar J, Chow CC, Albursan I, Frost JM, Ballard D, et al.

    EMBO Molecular Medicine DOI ↗

  3. Insights into plant regeneration: cellular pathways and DNA methylation dynamics

    Lee S, Park YS, Rhee JH, Chu H, Frost JM, Choi Y

    Plant Cell Reports DOI ↗

2023

5 papers

  1. H2A.X promotes endosperm-specific DNA methylation in Arabidopsis thaliana

    Frost JM, Lee J, Hsieh PH, Lin SJH, Min Y, Bauer M, Runkel AM, Cho HT, Hsieh TF, Fischer RL, et al.

    BMC Plant Biology DOI ↗

  2. Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation

    Cheng KCL, Frost JM, Sánchez-Luque FJ, García-Cañadas M, Taylor D, Yang WR, Irayanar B, et al.

    Epigenetics & Chromatin DOI ↗

  3. Distinct regulatory pathways contribute to dynamic CHH methylation patterns in transposable elements throughout Arabidopsis embryogenesis

    Lee J, Lee S, Park K, Shin SY, Frost JM, Hsieh PH, Shin C, Fischer RL, Hsieh TF, Choi Y

    Frontiers in Plant Science DOI ↗

  4. Embryo-specific epigenetic mechanisms reconstitute the CHH methylation landscape during Arabidopsis embryogenesis

    Hsieh PH, Frost JM, Choi Y, Hsieh TF, Zilberman D, Fischer RL

    BioRxiv (preprint) DOI ↗

  5. Regulation of human trophoblast gene expression by endogenous retroviruses

    Frost JM, Amante SM, Okae H, Jones EM, Ashley B, Lewis RM, Cleal JK, et al.

    Nature Structural & Molecular Biology DOI ↗

2022

1 paper

  1. Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

    Ashley B, Simner C, Manousopoulou A, Jenkinson C, Hey F, Frost JM, Rezwan FI, et al.

    eLife DOI ↗

2021

1 paper

  1. The DME demethylase regulates sporophyte gene expression, cell proliferation, differentiation, and meristem resurrection

    Kim S, Park JS, Lee J, Lee KK, Park OS, Choi HS, Seo PJ, et al.

    PNAS DOI ↗

2019

3 papers

  1. Nuclear chaperone ASF1 is required for gametogenesis in Arabidopsis thaliana

    Min Y, Frost JM, Choi Y

    Scientific Reports DOI ↗

  2. The catalytic core of DEMETER guides active DNA demethylation in Arabidopsis

    Zhang C, Hung YH, Rim HJ, Zhang D, Frost JM, Shin H, Jang H, et al.

    PNAS DOI ↗

  3. Regulation of transposable elements by DNA modifications

    Deniz Ö, Frost JM, Branco MR

    Nature Reviews Genetics DOI ↗

2018

1 paper

  1. FACT complex is required for DNA demethylation at heterochromatin during reproduction in Arabidopsis

    Frost JM, Lee J, Hsieh PH, Lin SJH, Min Y, Bauer M, Runkel AM, Cho HT, Hsieh TF, Fischer RL, et al.

    PNAS DOI ↗

2017

1 paper

  1. Control of DEMETER DNA demethylase gene transcription in male and female gamete companion cells in Arabidopsis thaliana

    Park JS, Frost JM, Park K, Ohr H, Park GT, Kim S, Eom H, et al.

    PNAS DOI ↗

2016

1 paper

  1. Optimized methods for the isolation of Arabidopsis female central cells and their nuclei

    Park K, Frost JM, Adair AJ, Kim DM, Yun H, Brooks JS, Fischer RL, Choi Y

    Molecules and Cells DOI ↗

2015

2 papers

  1. The role and interaction of imprinted genes in human fetal growth

    Moore GE, Ishida M, Demetriou C, Al-Olabi L, Leon LJ, Thomas AC, Abu-Amero S, et al.

    Philosophical Transactions of the Royal Society B DOI ↗

  2. Genome-wide methylation analysis in Silver–Russell syndrome patients

    Prickett AR, Ishida M, Böhm S, Frost JM, Puszyk W, Abu-Amero S, Stanier P, Schulz R, Moore GE, Oakey RJ

    Human Genetics DOI ↗

2014

2 papers

  1. Nucleoporin MOS7/Nup88 is required for mitosis in gametogenesis and seed development in Arabidopsis

    Park GT, Frost JM, Park JS, Kim TH, Lee JS, Oh SA, Twell D, Brooks JS, Fischer RL, Choi Y

    PNAS DOI ↗

  2. Cell-autonomous-like silencing of GFP-partitioned transgenic Nicotiana benthamiana

    Sohn SH, Frost J, Kim YH, Choi SK, Lee Y, Seo MS, Lim SH, Choi Y, Kim KH, Lomonossoff G

    Journal of Experimental Botany DOI ↗

2013

1 paper

  1. Epigenetic control of seed gene imprinting (book chapter)

    Ibarra CA, Frost JM, Shin J, Hsieh TF, Fischer RL

    Seed Genomics (Wiley) DOI ↗

2012

2 papers

  1. The speech gene FOXP2 is not imprinted

    Thomas AC, Frost JM, Ishida M, Vargha-Khadem F, Moore GE, Stanier P

    Journal of Medical Genetics DOI ↗

  2. Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach

    Moschidou D, Mukherjee S, Blundell MP, Drews K, Jones GN, Abdulrazzak H, Nowakowska B, et al.

    Molecular Therapy

2011

2 papers

  1. Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes

    Monk D, Arnaud P, Frost JM, Wood AJ, Cowley M, Martin-Trujillo A, Guillaumet-Adkins A, et al.

    Nucleic Acids Research DOI ↗

  2. The effects of culture on genomic imprinting profiles in human embryonic and fetal mesenchymal stem cells

    Frost J, Monk D, Moschidou D, Guillot PV, Stanier P, Minger SL, Fisk NM, Moore HD, Moore GE

    Epigenetics DOI ↗

2010

3 papers

  1. Evaluation of allelic expression of imprinted genes in adult human blood

    Frost JM, Monk D, Stojilkovic-Mikic T, Woodfine K, Chitty LS, Murrell A, Stanier P, Moore GE

    PLoS ONE DOI ↗

  2. Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells

    Frost JM, Udayashankar R, Moore HD, Moore GE

    PLoS ONE DOI ↗

  3. The importance of imprinting in the human placenta

    Frost JM, Moore GE

    PLoS Genetics DOI ↗

2009

2 papers

  1. Epigenetics, assisted reproductive technologies and growth restriction (book chapter)

    Frost JM, Abu-Amero S, Daelemans C, Moore GE

    Reproductive Genetics (CUP) DOI ↗

  2. Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression

    Monk D, Arnaud P, Frost J, Hills FA, Stanier P, Feil R, Moore GE

    Human Molecular Genetics DOI ↗

2008

1 paper

  1. The genetic aetiology of Silver–Russell syndrome

    Abu-Amero S, Monk D, Frost J, Preece M, Stanier P, Moore GE

    Journal of Medical Genetics DOI ↗

2007

1 paper

  1. Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight

    Apostolidou S, Abu-Amero S, O'Donoghue K, Frost J, Olafsdottir O, Chavele KM, Whittaker JC, Loughna P, Stanier P, Moore GE

    Journal of Molecular Medicine DOI ↗